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KMID : 0363420090230010141
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Journal of Korean Oriental Pediatrics
2009 Volume.23 No. 1 p.141 ~ p.158
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The Effect of KyungOcGogamibang on the Growth of the Rats
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Jung Bong-Kyun
Yun Hye-Jin
Lee Yu-Jin
Kang Mi-Sun
Baek Jung-Han
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Abstract
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Objectives: The purpose of this study is to find out the effect of KyungOcGogamibang(KOGE) on the growth of rats.
Methods: First of all, we divided male Sprague-Dawley rats into 4 groups(KOGE1, KOGE2, KOGE3 and control group). Then KOGE1, KOGE2 and KOGE3 groups were administered with KOGE water extracts once a day at a dosage of 250, 500, 1,000mg/kg respectively for 3 weeks. The control group was administered with normal saline in the same manner. We measured the rat’s body weight, amount of body weight increased, length of femur, serum GH, serum IGF-Ⅰ, serum TSH and serum testosterone after each week of administration.
Results: 1. There were significant changes of the rat’s body weight, the length of the femur, the level of GH, IGF-Ⅰand TSH in KOGE1 groups. 2. There were significant changes of the rat’s body weight, the length of the femur, the level of IGF-Ⅰand TSH in KOGE2 groups. 3. There were significant changes of the rat’s body weight, the length of the femur, the level of IGF-Ⅰand TSH in KOGE3 groups.
Conclusions: According to the results above, rat in KOGE group have been increased their body weight, length of femur, serum GH, serum IGF-1 compared to the control group. This study shows that groups of KOGE have an effect on promoting the growth, thus it is expected to treat growth problems for children.
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KEYWORD
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KyungOcGogamibang(KOGE), growth, body weight, length of the femur, GH, IGF-I, TSH
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